What is MST4?

MST4 is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Function: Mediator of cell growth. Modulates apoptosis
MST4 a S/T protein kinase of the STE20 family. Mst kinases adapt processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase area of Mst is appreciably akin to the kinase area of aggrandize STE20 kinase and added p21-activated kinases. otential advocate of corpuscle growth. Interaction with Golgi cast protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a aftereffect of stabilization of dimer formation. May aswell be activated by C-terminal cleavage. Note: This description may cover advice from UniProtKB.
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