Synonyms Lutidinic acid; Pyridine-2,4-dicarboxylic acid
Molecular Formula C7H5NO4
Molecular Weight 167.12
CAS Registry Number 499-80-9
JMJD2E(KDM5E) has been identified as a pseudogene, it displays similar specificity to that of JMJD2D(KDM5D) a H3K9 demethylase. In comparison to other JMJD2 family members JMJD2E is capable of very rapidly demethylating H3 lysine 9. This makes JMJD2E(KDM5E) an ideal model protein for elucidating the specificity of demethylation (3).JMJD2E(KDM5E) containing nickel in place of iron (II) has been co-crystallised with 2,4 pyridinedicarboxylic acid (2,4-PDCA). 2,4-PDCA complexes in the co-factor part of the active site and adopts the same coordination as that found in JMJD2A(KDM5A) in complex with 2,4-PDCA.
More about: JMJD2E + 2,4-PDCA sale
Read more: Proteases Enzyme
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