Abl2(also accepted as ARG (ABL Related Gene)) is a affiliate of the Abelson ancestors of non-receptor tyrosine kinase. ABL2 shares a top amount of arrangement attention with cABL and has agnate area alignment absolute an N-terminal SH3–SH2 kinase area assemblage followed by a C-terminal area absolute advancing sites for SH3 domains, F-actin and microtubules. Through its interactions with the cytoskeleton Abl2 plays a role in murine neurulation and it is appropriate for adhesion-dependent neurite aberration and synapse/dendrite stability. ABL2 has aswell a role in fibroblastic- and epithelial corpuscle adherence and migration. Abl2+ K00546 shares a amount of cellular authoritative functions with cABL. Targeted disruption of the cAbl gene in mice resulted in pleiotropic phenotypes including runtedness, top perinatal lethality, susceptibility to infections, and allowed deficiencies.
Like ABL1, Abl2 is circuitous in animal neoplastic diseases. Abl is up- or down-regulated in several solid tumors and oncogenic gene translocations involving the ETV6 gene accept been declared in animal astute leukemia. Previously we accept call the anatomy of the kinase area of ABL2 at 2.05 resolution in circuitous with the oncology biologic gleevec.
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