What is Cytokeratin-19 Fragments(CYFR21-1) quantitative detection Kit (TRFIA)?

Cytokeratin-19 Fragments(CYFR21-1) quantitative detection Kit (TRFIA) is performed using the Fujirebio Diagnostics CYFRA 21-1 Enzyme Immunoassay. Results obtained with different assay methods or kits cannot be used interchangeably.
CYFRA 21-1 assay may be a useful tumor marker for discriminating benign from malignant pleural effusion, especially in those of non-small cell lung cancer. The combined use of CEA and CYFRA 21-1 assay in the malignant effusion may increase the diagnostic yield compared with CEA or CYFRA 21-1 alone.
Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The term "cytokeratin" began to be used in the late 1970s (for example, see "Intermediate-sized filaments of human endothelial cells" by Franke, Schmid, Osborn and Weber) when the protein subunits of keratin intermediate filaments inside cells were first being identified and characterized. In 2006 a new systematic nomenclature for keratins was created and now the proteins previously called "cytokeratins" are simply called keratins. Over 25,000 published articles exist in the biomedical research literature that used the term "cytokeratin".
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