Functions of DAPK3

Death-associated protein kinase 3 is an agitator that in bodies is encoded by the DAPK3 gene.
Function
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis if overexpressed in beastly cells. These after-effects advance that DAPK3 may play a role in the consecration of apoptosis.
Unlike a lot of added beastly genes, murine (rat and mouse) DAPK3 has undergone accelerated change and diverged from the deeply conserved accord that is maintained from angle to human
DAPK3 Serine/threonine kinase which acts as a absolute regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin ablaze alternation phosphatase through phosphorylation of MYPT1 thereby acclimation the accumulation of the actin cytoskeleton, corpuscle migration, invasiveness of bump cells, bland beef abbreviating and neurite outgrowth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. Homodimer or forms heterodimers with ATF4. Both interactions crave an complete leucine attachment area and oligomerization is appropriate for abounding enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary circuitous which plays a role in caspase activation. Interacts with AATF and CDC5L. Note: This description may cover advice from UniProtKB.
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